Located in the heart of Palayam, the CSI Mateer Memorial Church is a cornerstone of Protestant Christian heritage in Kerala. Originally founded in 1838 by the London Missionary Society (LMS), it began as a simple chapel established through the efforts of early missionaries like Rev. John Cox and local supporters. 

The early congregation grew steadily under Rev. Cox, who formalized the church's structure through a trust deed open to all Protestant Christians. Over time, it also hosted Malayalam and Tamil services, serving both the local Christian community and visiting British officials. In 1893, following the death of Rev. Samuel Mateer-an influential missionary who significantly contributed to its growth-a plan was initiated to construct a larger building in his memory. By 1906, a new church building was completed at the LMS Compound under the guidance of Rev. Arthur Parker and dedicated by Rev. R.W. Thompson.

Architecturally, the church is distinguished by its Hallenkirche-style layout, Gothic arches, granite construction, and iconic square bell tower. It was not merely a change of building but a continuation of the same community, making it a rare example of living ecclesiastical heritage. Through centuries of transitions, it remains a vital spiritual space that has shaped the religious and educational landscape of Trivandrum, closely linked with institutions like University College and the city's early missionary schools.